Original scientific paper

Fused Pyrimidines. Part II: Synthesis and Antimicrobial activity of Some Furo[3,2-e]imidazo[1,2-c]pyrimidines and Furo[2,3-d]pyrimidines

M. M. H. Bhuiyan
Khandker M. M. Rahman
M. K. Hossain
M. A. Rahim
M. I. Hossain

Abstract

2-Amino-4,5-diphenylfuran-3-carbonitrile (2) reacted with N-[bis(methylthio)methylene]glycine ethyl ester (1) to afford a double cyclized product 5-methylthio-8,9-diphenylfuro[3,2-e]imidazo [1,2-c]pyrimidin-2(3H)-one (3). Compound 2 also reacts with benzonitrile to give 4-amino- 2,5,6-triphenylfuro[2,3-d]pyrimidine (4). Treatment of 2 with HCONH2, under reflux, afforded 4-amino-5,6-diphenylfuro[2,3-d]pyrimidine (5) which was then allowed to react with chloroacetaldehyde to give 8,9-diphenylfuro[3,2-e]imidazo[1,2-c]pyrimidine (6). Reaction of 2 with HCOOH gave 5,6-diphenylfuro[2,3-d]pyrimidin-4(3H)-one (7) which was then converted to its tosyl derivative (8). The antimicrobial activity of the synthesized compounds 2–8 was tested.

Keywords

Pyrimidines; furopyrimidines; furo-imidazo-pyrimidines; antimicrobial activity

Hrčak ID:

2553

URI

https://hrcak.srce.hr/2553

Publication date:

20.12.2005.

Article data in other languages: croatian

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