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Archives of Psychiatry Research : An International Journal of Psychiatry and Related Sciences, Vol. 59 No. 1, 2023.

Original scientific paper

https://doi.org/10.20471/may.2023.59.01.03

Psychiatric Symptoms in Women with Focal Cervical Dystonia - Exploring New Pathophysiological Pathways

Tihana Gilman Kuric ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Zvonimir Popović ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Svetlana Tomić ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Jagoda Kragujević ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Tea Mirošević Zubonja ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Tomislav Pučić ; Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia
Anamarija Petek Erić ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry, Osijek University Hospital Centre, Osijek, Croatia
Igor Kuric ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Dermatology and Venereology, Osijek University Hospital Centre, Osijek, Croatia

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Abstract

So far there is not much research considering female sex as a risk factor for developing focal cervical dystonia and concomitant psychiatric symptoms such as anxiety. New research proposes ideas of CD baseline pathophysiology targeting neurobiological mechanisms of gamma aminobutyric acid GABAergic function underlying sexual dimorphism and psychiatric symptoms as an intrinsic factor of the disease itself. Our research examines the connection between motor and non-motor symptoms in female patients suffering from focal cervical dystonia and their response to treatment, cit- ing the available literature and hypothesising whether it can be linked to previously described alterations in GABA levels.

Keywords

anxiety; dystonic disorders; gamma-aminobutyric acid; pain

Hrčak ID:

293896

URI

https://hrcak.srce.hr/293896

Publication date:

19.2.2023.

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