Case report

Regeneration of the Skeleton by Recombinant Human Bone Morphogenetic Proteins

Tomislav Smoljanović
Lovorka Grgurević
Mislav Jelić
Mario Kreszinger
Miroslav Hašpl
Dražen Matičić
Slobodan Vukičević
Marko Pećina

Abstract

Recombinant human bone morphogenetic proteins (rhBMPs) have past a long journey in human orthopaedic surgery
during the last 15 years. From the first reports of the use of rhBMPs in hostile environments such as critically-sized bone
defects, avascular femoral head necrosis, unstable thoracolumbar vertebral fractures, instability between the atlas and
axis due to rheumatoid arthritis; over the use for nonunions of long bones and the scaphoid, reconstructive and revision
surgeries of the hip, acute fractures, allograft nonunions, congenital pseudarthrosis, and various approaches of lumbar
and cervical spine fusions, rhBMPs overgrow to a safe and reliable device in the treatment of open tibial shaft fractures,
nonunions of long bone fractures, anterior lumbar interbody fusion and revision posterolateral lumbar fusions. Systematic
review of the published literature of rhBMPs is presented.

Keywords

recombinant human bone morphogenetic proteins (rhBMPs); orthopaedic applications

Hrčak ID:

26909

URI

https://hrcak.srce.hr/26909

Publication date:

3.9.2007.

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