Veterinarska stanica, Vol. 54 No. 5, 2023.
Original scientific paper
https://doi.org/10.46419/vs.54.5.10
Antimicrobial susceptibility and trends in antimicrobial resistance of bacterial pathogens isolated from dogs urinary tract infection i Croatia from 2012-2022
Gordan Kompes
; Croatian Veterinary Institute, Zagreb, Croatia
Boris Habrun
; Croatian Veterinary Institute, Zagreb, Croatia
Miroslav Benić
; Croatian Veterinary Institute, Zagreb, Croatia
Luka Cvetnić
; Croatian Veterinary Institute, Zagreb, Croatia
Silvio Špičić
; Croatian Veterinary Institute, Zagreb, Croatia
Sanja Duvnjak
; Croatian Veterinary Institute, Zagreb, Croatia
Irena Reil
; Croatian Veterinary Institute, Zagreb, Croatia
Željko Cvetnić
; Croatian Veterinary Institute, Veterinary Institute Križevci, Križevci, Croatia
Branka Šeol Martinec
; Faculty of Veterinary Medicine University of Zagreb, Croatia
Antonela Bagarić
; Croatian Veterinary Institute, Zagreb, Croatia
Abstract
Bacterial urinary tract infections (UTIs) occur commonly in dogs. Increase of bacterial resistance and using criticaly–important antimicrobials, especially in UTIs in dogs, concern because of emergence of multidrug resistant bacterial strains. The objectives of this study were to investigate prevalence and antimicrobial resistance of most frequently isolated bacterial isolates causing UTIs in dogs, and to show trends of antimicrobial resistance during 11 year period in Croatia. A total of 2721 dog urine samples were analysed and 1363 were positive for bacterial growth (50.1%). Escherichia coli was the most frequently isolated organism (47.3%), followed by coagulase positive Staphylococcus sp. (20.7%), Proteus sp. (14.7%), Enterococcus sp. (13.6%), beta-hemolitic Streptococcus sp. (11.7%), Pseudomonas aeruginosa (4,5%) and meticillin resistent coagulasa pozitive Staphylococcus sp. (3.4%). In Gram-negative bacteria the susceptibility rates were high for gentamicin, amikacin (77.9%-97.3%), marbofloxacin and ciprofloxacin (69.7%-98.4%). High susceptibility rates in Proteus sp. to beta-lactams (70.5%-86.7%) and in Escherichia coli to chloramphenicol (73.3%) and trimethoprim/sulfamethoxazole (72,7%) were noticed. In coagulase positive Staphylococcus sp. only few isolates were susceptible to penicilin (10.6%) and ampicillin (16.7%), followed by streptomycin, neomycin and tetracyclines (56.0%-66.0%). In beta-hemolitic Streptococcus sp. the lowest susceptibility rates were found for aminoglycosides, tetracyclines (8.2%-31.9%) and fluoroquinolones (31.5%-61.6%). Enterococcus sp. isolates showed highest susceptibility to amoxicillin/clavulanic acid (78.0%) and ampicillin (70.4%). Amikacin and chloramphenicol, with susceptibility rate of 89.3% and 80.9%, were the only drugs effective against meticillin resistant coagulase positive Staphylococcus sp. Trends during eleven years of investigation period showed increase of resistance in Escherichia coli and Proteus sp. to fluoroquinolones, ampicillin and amoxicillin/clavulanic acid, while in Escherichia coli increase of resistance to cephalosporins was also noticed. These results will help in drug selection for empirical treatment of UTIs in dogs and raising awareness of resonable use of antimicrobials.
Keywords
antimicrobial resistence; IUT; dogs; antimicrobial; sensitivity
Hrčak ID:
294770
URI
Publication date:
23.3.2023.
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