Original scientific paper
Analysis of Preincisional and Postincisional Treatment with Alpha2-Adrenoreceptor Agonist Clonidine Regarding Analgesic Consumption and Hemodynamic Stability in Surgical Patients
Jasminka Peršec
Damir Buković
Višnja Majerić-Kogler
Katarina Šakić
Zoran Peršec
Miro Kasum
Abstract
Preemptive analgesia aims to prevent the sensitization of central nervous system, hence the development of pathologic
pain after tissular injury. The aim of the study was to assess the effect of preincisional clonidine treatment on analgesic
consumption and hemodynamic stability compared to clonidine administered at the end of the operation and control
group. Ninety-one patients undergoing elective colorectal surgery were randomly assigned to four groups: peroral clonidine
before operation, epidural clonidine before operation, epidural clonidine at the end of operation, and epidural saline
before operation as a control group. After the operation, patient-controlled analgesia with epidural morphine was instituted.
Analgesic consumption, blood pressure and heart rate were obtained at 1, 2, 6 and 24 h postoperatively, and the cumulative
consumption of analgesics was assessed at the end of the study period. Significant differences (p<0.05) in postoperative
systolic blood pressure, with highest hemodynamic stability was observed at 1 h and 6 h in the group of patients
administered epidural clonidine before operation. In this group of patients we found significant reduction in analgesic
consumption during the study period (p<0.05), compared to other groups. The cumulative consumption of analgesics assessed
at the end of the study period was significantly reduced (p<0.05) in the group of patients administered epidural
clonidine before operation (8.40±3.74, respectively) as compared with the peroral clonidine before operation (16.79±5.75,
respectively), epidural clonidine at the end of the operation (11.11±4.24, respectively) and control group of patients (18.00
±6.45, respectively). Preincisional administration of epidural clonidine was associated with a significantly lower analgesic
use, lower cumulative analgesic consumption and greater hemodynamic stability, in comparison with other groups.
Keywords
epidural analgesia; patient-controlled analgesia; clonidine
Hrčak ID:
26947
URI
Publication date:
3.12.2007.
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