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Cardiologia Croatica, Vol. 18 No. 3-4, 2023.

Meeting abstract

https://doi.org/10.15836/ccar2023.69

Do we believe in drug-coated balloons – a single-center retrospective analysis

Krešimir Gabaldo orcid id orcid.org/0000-0002-0116-5929 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Ivan Bitunjac orcid id orcid.org/0000-0002-4396-6628 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Domagoj Mišković orcid id orcid.org/0000-0003-4600-0498 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Marijana Knežević Praveček orcid id orcid.org/0000-0002-8727-7357 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Antonija Raguž orcid id orcid.org/0000-0002-7032-2852 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Blaženka Miškić orcid id orcid.org/0000-0001-6568-3306 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Ivica Dunđer orcid id orcid.org/0000-0002-3340-7590 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia
Katica Cvitkušić Lukenda orcid id orcid.org/0000-0001-6188-0708 ; General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia

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Abstract

Keywords

coated balloons; stent; chronic coronary syndromes; bifurcation lesions

Hrčak ID:

295846

URI

https://hrcak.srce.hr/295846

Publication date:

16.3.2023.

Visits: 542 *

Copyright: 2023, Croatian Cardiac Society

Date received: 17 February 2023

Date accepted: 22 February 2023

Publication date (print and electronic): March 2023

Volume: 18

Issue: 3-4

Page: 69

Publisher ID: CC 2022 18_3-4_69

DOI: 10.15836/ccar2023.69

Article Information (continued)

Categories:

Subject: Extended Abstract

KEYWORDS: :

KEYWORDS:

Keyword: coated balloons

Keyword: stent

Keyword: chronic coronary syndromes

Keyword: bifurcation lesions

Do we believe in drug-coated balloons – a single-center retrospective analysis

[https://orcid.org/0000-0002-0116-5929] Krešimir Gabaldo[1][2][*]

[https://orcid.org/0000-0002-4396-6628] Ivan Bitunjac[1]

[https://orcid.org/0000-0003-4600-0498] Domagoj Mišković[1][2]

[https://orcid.org/0000-0002-8727-7357] Marijana Knežević Praveček[1][2]

[https://orcid.org/0000-0002-7032-2852] Antonija Raguž[1]

[https://orcid.org/0000-0001-6568-3306] Blaženka Miškić[1][2]

[https://orcid.org/0000-0002-3340-7590] Ivica Dunđer[1]

[https://orcid.org/0000-0001-6188-0708] Katica Cvitkušić Lukenda[1][2]

 

[1] General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia,

[2] Faculty of Dental Medicine and Health Osijek, Osijek, Croatia

Author notes:

Correspondence to: [*] ADDRESS FOR CORRESPONDENCE: Krešimir Gabaldo, Opća bolnica “Dr. Josip Benčević”, Andrije Štampara 42, HR-35000 Slavonski Brod, Croatia. / Phone: +385-98-1398-810 / E-mail: kresimir.gabaldo@gmail.com

Introduction: Drug-coated balloon (DCB) percutaneous coronary intervention (PCI) is the concept of treating coronary stenosis avoiding stent implantations. This „leave nothing behind“ concept is very attractive but still it is reserved for the minority of patients’ scenarios. While in small vessels (<2.75 mm) de novo lesions DCB were non inferior to second generation DES, in large vessels (>3.0mm) randomized data are lacking but there is growing evidence for the efficacy and safety. Also, there is little data favoring treating side branch bifurcation lesions while there is no data to support DCB-only concept in true bifurcation lesions. (1-3)

Patients and Methods: We analyzed data from the hospital information system and web-based database (CAD register) of patients who underwent urgent and elective PCI procedure in the General Hospital “Dr. Josip Benčević” in the last 3 years. CAD register was created in 2019 and contains patient and procedure specific information. We analyzed percentage of all DCB interventions, in stent restenosis (ISR) – de novo lesions ratio, and subanalysis of chronic vs acute coronary syndromes (CCS vs ACS) de novo lesions.

Results: In 2020 there were 29 (5.6%) DCB interventions of total PCI procedures, with 8 (27.6%) de novo DCB-only interventions. In 2021 we performed 48 (7.9%) DCB interventions and 26 (54. 2%) de novo DCB-only interventions, while in 2022 we performed 78 (12.6%) and 44 (56.4%) de novo DCB-only interventions. Most interventions were for acute coronary events 58 (74.3%), with TIMI 3 flow established in culprit vessels in more than 85% of cases, mostly in small vessels.

Conclusion: Use of the DCB only strategy for de novo lesions has tripled overall in 3 years at our institution. According to our experience, DCB-only PCI is safe and efficient strategy for treating variety of patients including STEMI. The advancements of DCB technologies facilitated the treatment of DCB only de novo lesions. Future studies are needed to evaluate the efficacy and safety DCB in large vessel interventions especially in diffuse atherosclerotic disease and bifurcations.

LITERATURE

1 

Cortese B, Micheli A, Picchi A, Coppolaro A, Bandinelli L, Severi S, et al. Paclitaxel-coated balloon versus drug-eluting stent during PCI of small coronary vessels, a prospective randomised clinical trial. The PICCOLETO study. Heart. 2010 August;96(16):1291–6. https://doi.org/10.1136/hrt.2010.195057 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20659948

2 

Jeger RV, Farah A, Ohlow MA, Mangner N, Möbius-Winkler S, Weilenmann D, et al. BASKET-SMALL 2 Investigators. Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial. Lancet. 2020 November 7;396(10261):1504–10. https://doi.org/10.1016/S0140-6736(20)32173-5 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/33091360

3 

Tang Y, Qiao S, Su X, Chen Y, Jin Z, Chen H, et al. RESTORE SVD China Investigators. Drug-Coated Balloon Versus Drug-Eluting Stent for Small-Vessel Disease: The RESTORE SVD China Randomized Trial. JACC Cardiovasc Interv. 2018 December 10;11(23):2381–92. https://doi.org/10.1016/j.jcin.2018.09.009 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30522667

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