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Acta clinica Croatica, Vol. 61. No. 3, 2022.

Original scientific paper

https://doi.org/10.20471/acc.2022.61.03.02

The Effect of Botulinum Toxin Type A in Patients with Essential Blepharospasm

Klara Gaćina orcid id orcid.org/0009-0004-5936-9790 ; Primary Care Medical Practice Mladen Prlina, Zagreb, Croatia
Mladen Lešin ; Department of Ophthalmology, Split University Hospital Centre, Split, Croatia; University of Split, School of Medicine, Split, Croatia
Dean Sarajčev ; Department of Ophthalmology, Split University Hospital Centre, Split, Croatia
Nina Rotim ; University of Zagreb, School of Medicine, Zagreb, Croatia

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Abstract

The aim of this study was to determine the effect of botulinum toxin type A and
satisfaction in patients with essential blepharospasm. The study included 12 subjects suffering from
essential blepharospasm who received therapy with botulinum toxin type A injections. Respondents
were given a Blepharospasm Disability Index (BSDI) survey before and three weeks after the procedure
with questions related to quality of life. They were also given a Jankovic Rating Scale with questions
related to the severity and frequency of symptoms. The overall level of difficulties was reduced, meaning
the quality of life increased after the application of botulinum toxin, and the study found that
the increase was statistically significant (p = 0.003). The severity of symptoms after the application of
botulinum toxin was reduced, which meant that there was a decrease in the severity of the difficulties,
and the study found a statistically significant difference (p=0.003). The frequency of symptoms was
reduced after botulinum toxin administration, and the study revealed a statistically significant difference
(p = 0.012). From the results of this study, we can determine that the use of botulinum toxin
type A increases the quality of life and that the severity and frequency of symptoms are statistically
significantly reduced.

Keywords

Notulinum toxin type A; Essential Blepharospasm; Dystonia; Blepharospasm Disability Index; Jankovic Rating Scale

Hrčak ID:

296044

URI

https://hrcak.srce.hr/296044

Publication date:

1.11.2022.

Article data in other languages: croatian

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