Acta clinica Croatica, Vol. 61. No. 3, 2022.
Original scientific paper
https://doi.org/10.20471/acc.2022.61.03.04
Estimation of the Glomerular Filtration Rate in Children with Hemophilia
Zrinko Šalek
orcid.org/0000-0002-1279-4974
; Division of Paediatric Haematology and Oncology, Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia
Matej Šapina
; Department of Paediatrics, University Hospital Centre Osijek, Osijek, Croatia; Josip Juraj Strossmayer University of Osijek Faculty of Medicine, Osijek, Croatia; Josip Juraj Strossmayer University of Osijek Faculty of Dental Medicine and Health, Osijek, Croatia
Karolina Kramarić
; Department of Paediatrics, University Hospital Centre Osijek, Osijek, Croatia; Josip Juraj Strossmayer University of Osijek Faculty of Dental Medicine and Health, Osijek, Croatia
Danko Milošević
; University of Zagreb School of Medicine, Zagreb, Croatia; Division of Paediatric Nephrology, Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia
Ernest Bilić
; Division of Paediatric Haematology and Oncology, Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia
Abstract
Estimated glomerular filtration rate (eGFR) is one of the best-performing methods
in evaluating kidney function. There are limited data regarding the estimated glomerular filtration
rate in children and young adults with hemophilia. The aim of this study was to determine the difference
between three commonly used estimated glomerular filtration rate equations in the pediatric
population in a cohort of patients with hemophilia. Our prospective study included 36 pediatric patients
with moderate or severe hemophilia. eGFR was calculated for each patient using the original
creatinine-based “bedside Schwartz” equation, the cystatin C-based equation and the creatinine-cystatin
C-based equation. The difference between the equations, calculated using the one-way repeated
ANOVA test, was statistically significant (p <0.001), and post hoc analysis found differences between
each method. Correlation analysis showed the strongest positive correlation between the bedside
Schwartz equation and creatinine-cystatin C-based equation (r=0.866) among the three methods examined.
A correlation between the three eGFR methods was present, but with significant differences
between them. Due to the observed differences between eGFR in pediatric patients with hemophilia,
further research is needed to find the optimal measurement method for eGFR. Nevertheless, we
recommend implementing eGFR equations in routine clinical monitoring of pediatric patients with
hemophilia.
Keywords
Estimated Glomerular Filtration rate; Hemophilia; Children; Cystatin C; Bedside Schwartz Equation; Creatinine-cystatin C-based Equation
Hrčak ID:
296066
URI
Publication date:
1.11.2022.
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