Original scientific paper
Effect of Olanzapine on Disruptive Behavior in Institutionalized Patients with Severe Intellectual Disability – A Case Series
Stipe Drmić
Tomislav Franić
Abstract
Considerable number of intellectual disabled people experience some form of disruptive behavior. Antipsychotics are
the most common treatment for these behaviors. Numerous patients were efficiently treated with thioridazine, recently
withdrawn. The authors describe a case series of »thioridazine responders« treated with olanzapine. Thirty three patients
with severe intellectual disability were recruited. All patients were assessed for seven types of disruptive behavior on five
point scale. Patients with severe behavior disturbances were included in treatment. The time points of assessment were
at day 0, 30, 60 and 180. Twenty one patient accomplished inclusion criteria. A significant decrease occurred at day 30
for all types of behavior. Total score, self injurious behavior, compulsive and destructive behavior showed further decrease
at day 60 and became stable until the end of study. Olanzapine appears to be efficacious in the treatment of disruptive
behavior in the intellectually disabled and could be substitute for thioridazine treatment.
Keywords
intellectual disability; disruptive behavior; antipsychotics; olanzapine
Hrčak ID:
27208
URI
Publication date:
7.7.2008.
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