Original scientific paper
Prognostic Significance of BsALP in Healing of Long Bone Fractures
Ante Muljačić
Renata Poljak-Guberina
Abstract
The aim of this work was to assess the relationship of both total alkaline phosphatase (ALP) and bone-specific alkaline
phosphatase (BsALP) with the course and outcome of operatively treated long-bone fractures The activity of total
ALP and BsALP was measured in 41 patients with a long bone fracture, comprising 26 men and 15 women. All patients
were treated operatively. Total ALP and BsALP levels were measured in sera on day 1, 7, 14 and 21 after sustaining injury.
Patient monitoring included X-rays. According to the outcome, patients were divided into two groups: the fast healing
group and the slow healing group. The levels of total ALP and BsALP showed parallel trends in the course of this
study. Depending on the healing outcome, on day 7 an increase in the case of slow healing, or a decrease in the case of fast
healing, for both BsALP and total ALP was observed. No difference was found between various sites of bone fracture.
This is an important result indicating the prognostic significance of total ALP and BsALP measurement in the monitoring
of long bone fracture healing. In addition, an early change in the level of these enzymes was associated with the efficiency
of the performed surgery.
Keywords
prognostic significance; BsALP; long bone fractures
Hrčak ID:
27214
URI
Publication date:
7.7.2008.
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