Original scientific paper
Anti-Citrullinated Antibodies, Radiological Joint Damages and Their Correlations with Disease Activity Score (DAS28)
Marija Glasnović
Ivica Bošnjak
Aleksandar Včev
Ivan Soldo
Elizabeta Glasnović-Horvatić
Silva Soldo-Butković
Jasna Pavela
Nikola Mićunović
Abstract
Determination of anti-citrullinated peptides (anti-CCP) specificity as a predictor of joint erosive changes, correlation
between their serum level and radiological damages as well as disease activity score (DAS28). A trial has been conducted
on a 211 patient sample fulfilling ACR criteria for rheumatoid arthritis (RA). There was assigned anti-CCP serum level,
disease activity score by the formula for DAS28(3)-CRP and assessed radiological changes degree after Steinbrocker
score. In 132 patient (62,559%) the serum anti-CCP concentration was positive for RA. Specificity of the test was 100%
and sensitivity 65% (Z=0,731, p=0,465). There is a medium intensity correlation between variables representing anti-
-CCP and Steinbrocker score. Pearson’s coefficient was 0,479 and Spearman’s rank correlation coefficient was 0,614, i.e.
statistically significant (p=0,000). There is no statistically significant correlation between variables representing anti-
-CCP and DAS28(3)-CRP. Anti-CCP are good RA predictor and their concentration correlate with radiological damages
degree.
Keywords
anti-citrullinated antibodies; rheumatoid arthritis; disease activity score; radiological damages
Hrčak ID:
27293
URI
Publication date:
4.1.2007.
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