Original scientific paper
Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene in Elderly Patients with Coronary Heart Disease
Biserka Bergman Marković
Mijo Bergovec
Željko Reiner
Jadranka Sertić
Josip Vincelj
Maja Marković
Abstract
Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene
polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in
the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers
and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by
discriminant analysis (c
2=25,77; df=16; p=0.0620). However, the use of univariate method demonstrated no correlation
between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with
higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the
elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.
Keywords
polymorphism ACE gene; ACE activity; CHD; elderly
Hrčak ID:
27314
URI
Publication date:
4.1.2007.
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