Case report, case study
Concomitant Chemoradiotherapy Using Carboplatin and Etoposide-induced Cutaneous Vasculitis in a Patient with Small Cell Lung Cancer
Krešimir Tomić
; Department of Oncology, University Clinical Hospital Mostar, Mostar, Bosnia and Her- zegovina;
Marija Kraljević
; Department of Oncology, University Clinical Hospital Mostar, Mostar, Bosnia and Her- zegovina;
Dragana Karan Križanac
; Department of Pathology, Cytology and Forensic Medicine, University Clini- cal Hospital Mostar, Mostar, Bosnia and Herzegovina;
Anita Gunarić
; Department of Dermatology and Venereology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina;
Snježana Šekerija Zovko
; Department of Surgery, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Abstract
Drug-induced vasculitis occurs after drug exposure and consequent
inflammation of small blood vessels which can lead to damage of affected tissue.
Rare cases of drug-induced vasculitis during chemotherapy or concomitant chemo-
radiotherapy have been described in the literature. Our patient was diagnosed with
stage IIIA (cT4N1M0) small cell lung cancer (SCLC). Four weeks after the application
of the second cycle carboplatin and etoposide (CE) chemotherapy, the patient de-
veloped cutaneous vasculitis and rash on the lower extremities. CE chemotherapy
was discontinued and symptomatic therapy with methylprednisolone was admin-
istered. On prescribed corticosteroid therapy, there was an improvement in local
finding. After completion of chemoradiotherapy, the patient continued treatment
with four cycles of consolidation chemotherapy with cisplatin (six cycles of chemo-
therapy in total). Clinical examination verified further regression of the cutaneous
vasculitis. Elective radiotherapy of the brain was performed after completion of
consolidation chemotherapy treatment. The patient was clinically monitored until
disease relapse. Subsequent lines of chemotherapy for platinum-resistant disease
were administered. The patient died seventeen months after diagnosis of SCLC. To
our knowledge, this is the first described case of a patient who developed vasculitis
of lower extremities during concomitant administration of radiotherapy and CE che-
motherapy as a part of the primary treatment for SCLC.
Keywords
vasculitis; skin diseases; chemoradiotherapy; lung neoplasms; treat- ment outcome
Hrčak ID:
299639
URI
Publication date:
14.9.2022.
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