Original scientific paper

Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions

Tanja Batinac
Ita Hadžisejdić
Gordana Brumini
Alen Ružić
Božidar Vojniković
Gordana Zamolo

Abstract

To gain insight into the role and association of cell cycle and apoptosis regulatory proteins and telomerase activity in
the course of progression of melanocitic lesions we have examined immunohistochemicaly, expression and the distribution
of p53, bcl-2, Ki-67 and telomerase in 25 samples of common and dysplastic nevi, and 45 samples of primary invasive
melanomas. Protein p53 expression was significantly increased in dysplastic as compared with common nevi and
melanomas (p<0.001). Bcl-2 protein expression was significantly increased in melanomas as compared with common
aquired and dysplastic nevi (p=0.001). Nevi and melanomas exhibited clear-cut differences in terms of Ki-67 expression.
Telomerase expression was significantly increased in melanomas as compared with common acquired (p=0.014) and
dysplastic nevi (p<0.001). Enhanced telomerase activity in association with increased bcl-2 expression in the course of
melanoma progression could contribute to development and progression of melanoma.

Keywords

bcl-2; melanoma; nevi; telomerase

Hrčak ID:

27415

URI

https://hrcak.srce.hr/27415

Publication date:

16.1.2007.

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