Review article
https://doi.org/10.26800/LV-145-supl1-8
Innovations in the treatment of asthma in children
Mirjana Turkalj
; Dječja bolnica Srebrnjak, Zagreb
Željka Vlašić Lončarić
; Medicinski fakultet Sveučilišta J. J. Strossmayera u Osijeku
Abstract
Asthma in childhood is a heterogeneous chronic inflammatory disease of the lower respiratory tract that manifests itself from early life with different phenotypes and endotypes, which can change during childhood. The paradigm of asthma treatment in children is changing from the concept of “one size fits all” to the concept of personalized medicine. According to the new GINA guidelines, asthma treatment is personalized and adapted to each patient in a continuous cycle of disease assessment, treatment and regular check-ups. In the control and treatment of asthma in children, the personalized concept is based on knowledge about the molecular heterogeneity of childhood asthma, the availability of new biological drugs, as well as innovative methods of monitoring adherence to treatment. However, still a significant percentage of children with asthma have uncontrolled or partially controlled asthma, and the personalized concept is still rarely applied in regular clinical practice. In particular, biomarkers are rarely determined and certain phenotypes/endotypes are recognized, which in practice is mainly carried out in rare centers, primarily to establish an indication for the use of biological therapy.
Keywords
ASTHMA, CHILDREN; PERSONALIZED TRETAMENT; GINA GUIDELINES
Hrčak ID:
300451
URI
Publication date:
17.4.2023.
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