Review article
https://doi.org/10.26800/LV-145-supl1-37
Stroke in children: Management recommendations and perspectives
Vlasta Đuranović
; Odjel za dječju neurologiju, Klinika za pedijatriju, Klinika za dječje bolesti Zagreb
Jadranka Sekelj Fureš
Ivana Đaković
Sanja Pejić Roško
Lana Lončar
Andrijana Pilon Far
Ana Tripalo Batoš
Tonći Grmoja
Goran Roić
Jasna Leniček Krleža
Abstract
Acute ischemic stroke in childhood (AIS) is a severe neurological damage associated with significant morbidity and mortality. It is among the top ten causes of death in children and therefore requires immediate diagnosis, brain imaging and rapid treatment within a given time frame. Diagnosing AIS in children is difficult and challenging, due to the diverse and non-pathognomonic presentation. Thanks to the implementation of protocols for IMU in children, guidelines for diagnosing stroke (primarily magnetic resonance imaging), the establishment of pediatric stroke centers and specific therapy for high-risk patients, the overall mortality from IMU in children is
decreasing, despite the increase in incidence in recent decades. Therefore, the main goal is early recognition of AIS in childhood, standardized approach and early threatment (individual approach on a case-by-case basis) in high- risk patients. Newer knowledge about non-atherosclerotic arteriopathy, which is the most common cause of AIS in childhood and which represents the most important predictor of recurrent AIS, requires new longitudinal and multicenter studies that will likely contribute to a better understanding of the infectious, parainfectious and inflammatory mechanisms of AIS in childhood and the development of predictive biomarkers of disease
progression.
Keywords
ISCHEMIC STROKE IN CHILDHOOD; DIAGNOSTIC PROTOCOL; THERAPEUTIC GUIDELINES
Hrčak ID:
300864
URI
Publication date:
17.4.2023.
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