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Collegium antropologicum, Vol. 30 No. 3, 2006.

Original scientific paper

Gonadal Cell Proliferation Dimorphism

Marianthi Balla
Roxani Angelopoulou
Giagkos Lavranos
Panagiota Manolakou

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Abstract

Dimorphism between testis and ovary in germ cells proliferative behavior, shows remarkable differences in foetal and
neonatal period 14.5 days post conception (dpc) – 7 days post partum (dpp). Immunostaining of the foetal testis, with
the PCNA and Ki-67 antibodies estimation of Labeling Index (LI), reveals increasing germ cells population until birth.
Afterwards, a sharp decline in the first 3 days of postnatal life and a transient increase, between 3 and 5 dpp, is observed.
Then, the mitotic activity of germ cells ceases. In the foetal ovary, germ cells proliferation reaches a peak value before
birth, decreasing thereafter. Somatic (Sertoli or follicular) cells behave similarly in both sexes. Increased mitotic activity
is observed throughout the examined period. Thus, the gonadal dimorphism in proliferative behavior, concerns only
germ cell lineage and is established during the foetal and neonatal period.

Keywords

dimorphism; testis; ovary; PCNA; Ki-67; germ cells; Sertoli cells; follicular cells

Hrčak ID:

27526

URI

https://hrcak.srce.hr/27526

Publication date:

12.5.2006.

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