Original scientific paper
Association of Two Genetic Variations of Lipoprotein Lipase, S447X and Hind III, with Coronary Artery Disease and Hypertriglyceridemia
Daria Pašalić
orcid.org/0000-0002-5741-6168
Goran Ferenčak
Branka Gršković
Mihajlo Šesto
Ana Stavljenić-Rukavina
Abstract
This study was performed to assess the effect of the S447X and Hind III lipoprotein lipase gene polymorphisms on development
of coronary artery disease and hypertriglyceridemia. The study included 132 patients and 98 healthy control
subjects of Croatian descent. The lipoprotein lipase S447X polymorphism was associated with coronary artery disease
and hypertriglyceridemia, as indicated by the lower frequency of S447 allele in the patient group (p=0.005) and odds ratio
(O.R=0.40, p=0.006). The patient and control groups also showed a significant difference in the distribution of Hind
III/S447X genotype combinations (p=0.013). There were no significant associations with lipid parameters for any genotype
or genotype combination in the patient group. Frequencies of the S447X polymorphism and S447X/Hind III combinations
differed between the CAD/TG and control group, thus these polymorphisms may be associated with CAD and
hypertriglyceridemia.
Keywords
coronary artery disease; hypertriglyceridemia; lipoprotein lipase; polymorphism; Croatia
Hrčak ID:
27589
URI
Publication date:
12.5.2006.
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