Original scientific paper

Esomeprazole Versus Pantoprazole for Healing Erosive Oesophagitis

Aleksandar Včev
Ivana Begić
Rajko Ostojić
Dragan Jurčić
Dubravko Božić
Ivan Soldo
Rudika Gmajnić
Goran Kondža
Eyad Khaznadar
Nikola Mićunović

Abstract

The aim of this study was to compare the efficacy of esomeprazole and pantoprazole with regard to healing and relief
from gastroesophageal reflux disease-related symptoms. I this multicentre, randomized, single-blind study 180 patients
(ITT population) diagnosed with endoscopically proven GERD grade A,B,C received esomeprazole (40 mg once daily
(o.d.), n=90) or pantoprazole (40 mg o.d., n=90). Healing and relief from GERD-related symptoms were assessed at first
and final visit (after 4 or 8 weeks of treatment). Esomeprazole 40 mg provided significantly greater healing than pantoprazole
40 mg after 4 weeks of treatment in patients with EE (77.8% vs. 72.2%). Esomeprazole-treated patients were
healed after up to 8 weeks of treatment similar those treated with pantoprazole (92.2% vs. 91.1%). The proportion of
heartburn-free days was similar in patients treated with esomeprazole and to those treated with pantoprazole.

Keywords

gastroesophageal reflux disease; GERD; esomeprazole; pantoprazole

Hrčak ID:

27602

URI

https://hrcak.srce.hr/27602

Publication date:

12.5.2006.

Visits: 6.874 *