Original scientific paper
Pregnancy Outcome after Treatment with Radioiodine for Differentiated Thyroid Carcinoma
Antonija Balenović
Marko Vlašić
Zdenko Sonicki
Davor Bodor
Zvonko Kusić
Abstract
The aim of the study was to investigate the influence of radioiodine (RAI) therapy on pregnancies and the health status
of children born to mothers who had received therapeutic doses of I-131 for differentiated thyroid carcinoma (DTC).
Gestational histories of 76 women treated for DTC from 1971–2005 were retrospectively analyzed. The outcome of 49
pregnancies after RAI was: 35 children (72%), 5 (10%) miscarriages and 9 (18%) induced abortions. RAI did not adversely
affect the rate of successful delivery and live birth demographics. Congenital malformation and first year mortality
were not observed. The children's ages range from 1 month to 29 years (X±SD=8.0±8.4). A higher therapeutic dose
(100 mCi) did not significantly alter the pregnancy outcome. There is no reason to discourage females treated with
I-131 from becoming pregnant. Patients should avoid pregnancy after RAI administration for 1 year.
Keywords
differentiated thyroid carcinoma; radioiodine; dose; pregnancy
Hrčak ID:
27632
URI
Publication date:
13.12.2006.
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