Case report

Review and New Insights on Wegener Granulomatosis

Jelena Juri
Neda Stiglmayer
Maarten Mourits

Abstract

The purpose of this paper is to presentWegener granulomatosis manifesting in its periocular form. Review with new
developments in understanding of the etiopathogenesis, clinical and laboratory findings as well as therapy modalities
are shown through a series of patients gathered in collaboration with colleagues from UMC Utrecht, Netherlands. In
the period from 1992 until 2004 the group of 54 patients with established diagnosis of Mb. Wegener were observed. 13
patients developed periocular form but only 2 presented it as initial symptoms. Lacrimal stenosis and orbital infiltration
were predominant periocular symtoms while nasal manifestations were predominant systemic symptoms of the
disease. Different treatment modalities were employed showing that orbital disease is difficult to treat in spite of satisfying
systemic answer to immunosuppressives which calls for alternative solutions.

Keywords

periocular Wegener; ANCA vasculitis; specific immunosuppression

Hrčak ID:

27896

URI

https://hrcak.srce.hr/27896

Publication date:

20.6.2005.

Visits: 1.019 *