Original scientific paper

Trabeculectomy with Mitomycin C in Glaucoma Associated with Uveitis

Katia Novak-Lauš
Zdravko Mandić
Renata Iveković
Jadranka Koršić
Eugenia Tedeschi-Reiner
Sanja Masnec-Paškvalin
Lovro Bojić

Abstract

The patients with uveitic glaucoma are at high risk for failure following drainage surgery because of young age of
these patients, preoperative long-term control of inflammation and postoperative complications. Twenty-two trabeculectomies
performed in 22 patients with uveitic glaucoma were retrospectively evaluated to analyze the effect of
intraoperative application of mitomycin C (MMC). Success rates, postoperative levels of intraocular pressure (IOP)
and postoperative complications were studied. After a mean follow-up of 10.6 months (range, 5–28 months), 15 patients
(68.2%) achieved IOP of 21mmHg or less without antiglaucoma medications. There were statistically significant
reduction in IOP postoperatively during the period studied (p<0.001). Early postoperative complications included chorioidal
detachment (9.1%), shallow anterior chamber (9.1%), hyphema (13.6%), macular edema (4.5%) and raised IOP
(27.3%). Late postoperative complications included exacerbation of uveitis (4.5%), macular edema (4.5%), cataract
(22.7%) and raised IOP (31.8 %). The eyes with raised IOP needed additional antiglaucoma medication. The results of
this retrospective and uncontrolled study suggest that intraoperative application of MMC may be a good option for enhancement
of short-term trabeculectomy success rates in patients with uveitic glaucoma.

Keywords

trabeculectomy; mitomycin C; uveitic glaucoma

Hrčak ID:

27905

URI

https://hrcak.srce.hr/27905

Publication date:

20.6.2005.

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