Original scientific paper
The Significance of Salivary and Serum Interleukin 6 and Basic Fibroblast Growth Factor Levels in Patients with Sjögren's Syndrome
Vanja Vučićević Boras
Nada Čikeš
Josip Lukač
Ana Cekić-Arambašin
Mišo Virag
Andrija Bošnjak
Abstract
Role of various cytokines have been implicated in the development and perpetuation
of Sjögren's syndrome (SS), but no specific cytokine could be determined as a major contributor
to the SS. Salivary and serum interleukin 6 (IL-6) levels have been studied previously
in patients with SS, but data upon salivary and serum basic fibroblast growth
factor (bFGF) in SS are lacking. The aim of this study was to evaluate levels of salivary
and serum IL-6 and bFGF in 18 patients with SS, age range 32–79, mean 54.05 years.
Control group consisted of 23 healthy participants, mean age 25 years. Serum IL-6 and
bFGF levels were not significantly different between patients with SS and healthy controls.
Elevated levels of salivary IL-6 and bFGF in patients with SS when compared to
the healthy controls were found (p<0.001). We might speculate that higher levels of salivary
IL-6 and bFGF in patients with SS might originate from local production probably
having source in the salivary glands.
Keywords
salivary cytokines; serum cytokines; Sjögren's syndrome
Hrčak ID:
28063
URI
Publication date:
28.12.2004.
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