Original scientific paper
Lispro Insulin and Metformin Versus Other Combination in the Diabetes Mellitus Type 2 Management after Secondary Oral Antidiabetic Drug Failure
Slaven Kokić
Damir Buković
Maja Radman
Vesna Čapkun
Nikica Gabrić
Vesna Lesko
Deni Karelović
Tajana Stančerić
Abstract
The purpose of the study was to find out differences between treatments of diabetes
type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment
were compared: lispro insulin in combination with metformin, glimepiride and
metformin combination or two daily doses of biphasic insulin 30/70 together with bed
-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly
distributed into 3 different treatment groups. Fasting and postprandial glucose
were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange
chromatography. HbA1c significantly decreased in all three study groups. The
decrease was mostly expressed among patients treated with lispro and metformin. When
focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro
therapy has greater impact on the overall metabolic control (decrease in level of
HbA1c) in comparison with the above mentioned more traditional approaches.
Keywords
lispro insulin; metformin; NIDDM; antidiabetic drug
Hrčak ID:
28084
URI
Publication date:
16.6.2003.
Visits: 1.840 *