Original scientific paper
Diagnostic Value of Cytology and Colposcopy for Squamous and Glandular Cervical Intraepithelial Lesions
Marija Pajtler
Silvana Audy-Jurković
Ana Ovanin-Rakić
Zvonimir Makarović
Miodrag Milojković
Nikola Ljubojević
Abstract
The main objective of work was to determine a diagnostic value of cytology and colposcopy
as a method of screening and differential diagnosis, as well as to determine the
relative value of some colposcopic features of squamous and glandular cervical intraepithelial
lesions. Cytological diagnosis and colposcopy findings is compared with histological
ones for 187 patients with intraepithelial lesions (142 squamous and 45 glandular
ones with or without squamous components) and determined the sensitivity and
positive predictive value of cytology and colposcopy, including the types of colposcopic
abnormalities associated with squamous/glandular intraepithelial lesions. The sensitivity
of cytology as a screening method for SIL (squamous intraepithelial lesions) is
89% and for GIL (glandular intraepithelial lesions) 98%. Positive predictive value of
differential cytology for SIL is 59% and for GIL 53%. Sensitivity of colposcopy for both
lesions' type is 87%. Acetowhite epithelium occurs far more often with SIL, whereas
atypical vessels and unequal, dilated gland openings with GIL (p<0.05). Cytology and
colposcopy as screening methods have a high sensitivity. Nevertheless, cytology is far
more accurate in determining differential diagnosis of SIL than GIL and some colposcopy
abnormalities suspicious of GIL should be further tested in praxis.
Keywords
cervix; cytology; colposcopy; squamous intraepithelial lesions (SIL); Glandular intraepithelial lesions (GIL)
Hrčak ID:
28092
URI
Publication date:
16.6.2003.
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