Original scientific paper

https://doi.org/10.20471/acc.2023.62.01.04

Association between High Mobility Group Box 1 Protein Gene (Rs41369348) Polymorphism and Immunoglobulin A Vasculitis in Children

Mateja Batnožić Varga ; Department of Pediatrics, Josip Juraj Strossmayer University of Osijek, Osijek Faculty of Medicine, Osijek University Hospital Center, Osijek, Croatia
Mario Šestan ; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Jasenka Wagner ; Department of Medical Biology and Genetics, Josip Juraj Strossmayer University of Osijek, Osijek Faculty of Medicine, Osijek, Croatia
Kristina Crkvenac Gornik ; Clinical Department of Laboratory Diagnostics, University of Zagreb School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Nastasia Kifer ; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Marijan Frković ; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Laura Stefinovec ; Department of Pediatrics, Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek University Hospital Center, Osijek, Croatia
Valentina Vučemilović Jurić ; Department of Medical Biology and Genetics, Josip Juraj Strossmayer University of Osijek, Osijek Faculty of Medicine, Osijek, Croatia
Danica Grgurić ; Department of Pediatrics, Zagreb University Hospital Center, Zagreb, Croatia
Silvija Pušeljić ; Department of Pediatrics, Josip Juraj Strossmayer University of Osijek, Osijek Faculty of Medicine, Osijek University Hospital Center, Osijek, Croatia
Marija Jelušić ; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb University Hospital Center, Zagreb, Croatia

Abstract

Immunoglobulin A vasculitis (IgAV) or Henoch-Schönlein purpura is the most
prevalent systemic small vessel vasculitis in childhood. High mobility group box 1 protein (HMBG1)
is a pleiotropic cytokine that functions as a pro-inflammatory signal, important for the activation of
antigen-presenting cells and propagation of inflammation. HMGB1 is implicated in the pathophysiology
of a variety of inflammatory diseases. The aim of this study was to investigate the role of single
nucleotide polymorphism rs41369348 for HMGB1 gene in the susceptibility and clinical features
of patients meeting the classification criteria for IgAV. DNA was extracted from blood cells of 76
children with IgAV and 150 age-matched healthy controls. Clinical data and laboratory parameters
were collected for all IgAV patients. Although there was a higher frequency of heterozygous A/delA
genotype of this gene polymorphism in IgAV group as compared with control group, no genotype
difference was observed between these two groups. No statistically significant genotype differences
were disclosed when patients with different IgAV clinical features were compared. In conclusion, in
this study, polymorphism rs41369348 for HMGB1 was not associated with increased susceptibility to
childhood IgAV, its severity or different clinical manifestations.

Keywords

Henoch-Schӧnlein purpura; HMGB1 protein; Single nucleotide polymorphism

Hrčak ID:

307135

URI

https://hrcak.srce.hr/307135

Publication date:

1.4.2023.

Article data in other languages: croatian

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