Original scientific paper
HLA Class II Haplotypic Association and DQCAR Microsatellite Polymorphisms in Croatian Patients with Psoriasis
Z. Grubić
R. Žunec
M. Kaštelan
E. Čečuk-Jeličić
F. Gruber
A. Kaštelan
Abstract
The purpose of the present study was to investigate polymorphism of HLA class II
haplotypic associations (HLA-DRB1, -DQA1, -DQB1) and DQCAR alleles in 78 Croatian
patients with psoriasis. Patients were divided into two groups according to a family
history of disease and age of onset: type I (positive family history and early onset)
and type II (negative family history and late onset). The difference in frequency of HLA
class II haplotypic associations between type I patients and controls was observed for
the following combinations: HLA-DRB1*0701, -DQA1*0201, -DQB1*02 (23.6% vs. 7.2%;
p < 0.001), HLA-DRB1*0701, -DQA1*0201, -DQB1*0303 (8.5% vs. 1.3%; p = 0.0018) and
HLA-DRB1*1601, -DQA1*0102, -DQB1*0502 (2.8% vs. 9.3%; p = 0.06). The difference
between type II psoriasis and controls for association: HLA-DRB1*1501, -DQA1*0102,
-DQB1*0602 is not significant (20.0% vs. 8.9%; p = 0.06). The significantly higher frequency
of DQCAR 113bp and 119bp alleles in patients with type I psoriasis is a result of
linkage disequlibrium of these alleles with both HLA-DRB1*0701 haplotypic associations.
Analysis of DQCAR alleles in the HLA-DRB1*0701 haplotypic associations in patients
with psoriasis vulgaris and matched controls did not reveal any difference in
polymorphism of DQCAR alleles. These data suggest that HLA-DRB*0701 haplotypic
combinations are associated with type I but not for type II psoriasis in the Croatian population.
DQCAR polymorphism is not useful genetic marker to distinguish susceptible
HLA class II haplotypic association.
Keywords
Hrčak ID:
28245
URI
Publication date:
17.6.2002.
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