Original scientific paper
HLA Class I and Class II Polymorphism in the Population of Rijeka, Croatia
M. Crnić-Martinović
K. Vujaklija-Stipanović
S. Ristić
M. Fućak
M. Kapović
M. Weiner
J. Sepčić
Abstract
The aim of the study was to examine frequencies of HLA-A, -B, -DR antigens and
haplotypes in population of Rijeka and to compare them with general Croatian and European
populations. The subjects were 117 unrelated healthy blood donors. The antigens
with the highest frequencies were: A2 (27.2%), A9 (16.3%), B5 (14.8%), B12
(11.8%), B18 (11.8%), DR5 (21.6%) and DR6 (13.8%). Comparison of HLA antigens frequencies
has shown statistically significant difference in 1 antigen with Croatian population
and in 8 antigens with European population. The HLA haplotypes with high frequencies
included HLA-A2, B5 (6.84%), HLA-A2, B12 (6.84%), HLA-A2, B18 (6.84%),
HLA-B12, DR2 (9.78%) and HLA-B18, DR5 (6.84%). The antigen B5 showed strongest
association with DR5 (6.41%; LD = 1.30) as in general Croatian and in some European
populations. The results have shown great diversity of HLA haplotypes in Rijeka population
which can be the result of admixture with neighborhood immigrating populations
during the history.
Keywords
Hrčak ID:
28246
URI
Publication date:
17.6.2002.
Visits: 1.026 *