Original scientific paper
Allele Frequencies of Alpha-1-Antitrypsin (PI) in the Balkans
H.-G. Scheil
S. Schuhen
W. Huckenbeck
H. D. Schmidt
Abstract
The phenotype and allele frequencies of alpha-1-antitrypsin has been studied by an
IEF technique (pH 4.2–4.9) in ten population samples from the Balkans. The allele frequencies
varied from 0.6667 to 0.7361 (*M1), 0.1100 to 0.1793 (*M2), 0.0992 to 0.1700
(*M3), 0 to 0.0105 (* S), 0 to 0.0078 (*Z) and 0 to 0.0172 (others). The results were compared
with data from South and Middle European populations from the literature.
Most of the populations form a cluster with small genetic distances, and a weak relationship
to geographical distributions. In contrast, the samples from Southern France,
the Iberian Peninsula and Madeira form a clearly separated cluster. The differences are
mainly based on high frequencies of PI*S in the latter populations.
Keywords
Hrčak ID:
28280
URI
Publication date:
16.12.2002.
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