Original scientific paper
https://doi.org/10.21857/m8vqrtgl09
Effect of intrathecal morphine on pain score in total hip arthroplasty
Anja Mandaric
Zrinka Orešković
Ivan Marić
Marijana Žura
Sandra Morović
Abstract
Introduction: The advantage of intrathecal morphine is due to its delivery into the subarachnoid space with direct access to opiate receptors and ion channels, while clinical duration of action can be as long as 20 hours. Joint replacement surgery is reported to be one of the most painful surgical procedures. The key factor for short postoperative length of stay and rapid functional recovery is pre-operative, intraoperative and postoperative analgesia. Spinal anaesthesia incorporating intrathecal morphine has been used as a systemic opioid-sparing technique. The most frequently investigated dose of intrathecal morphine was 100 μg.
Materials and Methods: In this study, spinal anaesthesia with the addition of morphine for intrathecal administration at a dose of 200 μg and 250 μg was administered to patients who underwent surgery for total hip arthroplasty and VAS pain scale was monitored postoperatively in the next 24 hours. The study group was compared to a group of patients who received standard intravenous analgesia postop- eratively.
Results: Intrathecal application of morphine improves pain management in the first 24 postoperative hours in comparison to a control group who has received a systemic combination of opioid and non- opioid analgesics as part of postoperative analgesia.
Conclusions: The use of intrathecal morphine at a dose of 200 μg or 250 μg is an extremely good anal- gesic method in the postoperative period after surgery for total hip arthroplasty.
Keywords
Intrathecal; Hip arthroplasty; Morphine; Pain management; Regional anaesthesia
Hrčak ID:
308338
URI
Publication date:
25.6.2023.
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