Original scientific paper

https://doi.org/10.20471/acc.2023.62.02.12

The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis

Ines Šiško Markoš orcid.org/0000-0001-6425-0701 ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia *
Maja Franceschi ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Valentina Vidranski ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Pave Markoš ; Department of Gastroenterology and Hepatology, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Tomislav Jukić orcid.org/0000-0001-5631-164X ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Faculty of Medicine of Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ana Fröbe orcid.org/0000-0002-5834-9841 ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Vanja Bašić Kes ; School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

* Corresponding author.

Abstract

The concentration of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α)
in the blood is higher in patients with active multiple sclerosis (MS) compared to those with inactive
disease. The concentration of IL-6 and TNF-α in the blood is higher in patients with Hashimoto’s
thyroiditis (HT) compared to those with a healthy thyroid. The aim of the study was to assess whether
serum IL-6 and TNF-α levels correlated with saliva in patients with inactive MS and whether there was
a difference in these groups of patients depending of thyroid status. We also examined the correlation
of thyroid stimulating hormone (TSH) levels with thyroid status. The study included 54 patients in the
inactive phase of MS. The level of cytokines in the blood was determined by chemiluminescence, and in
saliva by ELISA. Blood and saliva IL-6 levels showed positive correlation, while blood and saliva TNF-α
levels were not correlated. There was a significantly higher TSH level in patients with inactive MS with
positive thyroid antibodies, without therapy, compared with those with negative antibodies.

Keywords

Interleukin-6; TNF-α, Multiple sclerosis; Hashimoto’s thyroiditis; Saliva

Hrčak ID:

308766

URI

https://hrcak.srce.hr/308766

Publication date:

1.8.2023.

Article data in other languages: croatian

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