Review article
https://doi.org/10.26800/LV-145-supl5-18
Cholestasis in infants
Matea Kovačić Perica
orcid.org/0009-0006-7897-1714
; Zavod za gastroenterologiju, hepatologiju i prehranu, Klinika za pedijatriju, KBC Zagreb
*
Mirna Natalija Aničić
Jurica Vuković
orcid.org/0000-0001-8675-9170
* Corresponding author.
Abstract
Cholestasis is a disorder of bile production and/or flow that leads to the retention of bile in the liver. It is found in 1:2500 term infants, typically during the first three months of life. Conjugated hyperbilirubinemia is a biochemical manifestation of cholestasis defined as a conjugated bilirubin > 17 umol/L and/or > 20% of the total bilirubin. Cholestasis is always pathological and requires extensive workup. The most common individual causes of cholestasis are biliary atresia, infection, parenteral nutrition-associated liver disease, and alpha-1 antitrypsin deficiency. A quarter of patients in whom the etiology of cholestasis remains unexplained are diagnosed with idiopathic neonatal hepatitis. Clinical manifestations of cholestasis are jaundice, pruritus, light-colored stools, and dark urine. Impaired absorption of fat and fat-soluble vitamins, malnutrition, and pruritus are challenging clinical problems encountered in these patients. Conclusion: Cholestasis in infancy is a rare condition that is often caused by life-treatening diseases, and therefore the main task of every pediatrician is to recognize these patients in time and refer them for further workup.
Keywords
ICTERUS; CHOLESTATIC JAUNDICE; CHOLESTASIS; BILIARY ATRESIA; NEONATAL HEPATITIS
Hrčak ID:
309018
URI
Publication date:
10.10.2023.
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