Review article

https://doi.org/10.33004/reumatizam-69-2-5

Ibuprofen – induced toxic epidermal necrolysis – A CASE REPORT

Indira Melezović ; Clinic for cardiovascular disease and rheumatism, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina *
Samir Mehmedagić
Edin Begić
Mevludin Mekić
Emela Čvorak

* Corresponding author.

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, life-threatening mucocutaneous hypersensitivity reactions. The inflammatory response is mediated by cytotoxic T lymphocytes and NK (natural killer) cells with cytotoxic proteins and cytokines as mediators in the onset of cell apoptosis. Drugs are responsible for about 95% of cases of toxic epidermal necrolysis. Although non-steroidal anti-inflammatory drugs (NSAID) are classified as drugs that can potentially lead to this hypersensitivity reaction, a small number of cases have been described in the literature regarding the occurrence of this reaction to the use of ibuprofen. We present the case of a 58-year-old man who developed symptoms of TEN seven days after using ibuprofen. The treatment of toxic epidermal necrolysis is still a matter of debate. Given that there is no uniform protocol for treatment, and the lethal outcome in such conditions occurs in about 40% of cases, each presented case is significant in terms of considering the effectiveness and improvement of the therapeutic approach.

Keywords

toxic epidermal necrolysis, Stevens-Johnson syndrome, ibuprofen, sepsis

Hrčak ID:

309199

URI

https://hrcak.srce.hr/309199

Publication date:

22.10.2023.

Article data in other languages: croatian

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