Case report, case study
Segmental Erythema Multiforme: An Unusual Drug Reaction to Anastrozole
Sanja Poduje
; University Hospital Center Sestre Milosrdnice, Department of Dermatovenereology, Zagreb, Croatia
Luka Vujević
; University Hospital Center Sestre Milosrdnice, Department of Dermatovenereology, Zagreb, Croatia
Nika Filipović
orcid.org/0000-0001-8229-9373
; University Hospital Center Sestre Milosrdnice, Department of Dermatovenereology, Zagreb, Croatia
Majda Vučić
; University Hospital Center Sestre Milosrdnice, Department of Pathology “Ljudevit Jurak”, Zagreb, Croatia
Marija Buljan
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Abstract: Erythema multiforme (EM) is an immune-mediated, muco-
cutaneous hypersensitivity syndrome that can occur as a result of vari-
ous medications, including a wide range of antineoplastic and hormonal
drugs. Anastrozole, a nonselective aromatase inhibitor used in breast
cancer management has been associated with different cutaneous side ef-
fects, of which EM is rarely seen and usually in a minor or major form with
typical target lesions.
This is a short report of a patient who developed a rare cutaneous side
effect after the use of aromatase inhibitor anastrozole – segmental erythe-
ma multiforme in cancer-affected area. Cutaneous adverse effects limited
to cancer-affected breast are extremely rare but should be considered in
everyday dermatological practice. We find this case instructive not only
because of the rarity of the segmental EM, but also because, contrary to
classical teaching, drug eruption due to anastrozole occurred months, not
days after the initiation of therapy.
Keywords
erythema multiforme; drug reaction; anastrozole; breast cancer therapy; hypersensitivity syndrome
Hrčak ID:
311537
URI
Publication date:
16.3.2023.
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