Original scientific paper

https://doi.org/10.5599/jese.2039

A simple, sensitive and cost-effective electrochemical sensor for the determination of N-acetylcysteine

Peyman Mohammadzadeh Jahani ; School of Medicine, Bam University of Medical Sciences, Bam, Iran
Somayeh Tajik ; NanoBioelectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran
Fariba Garkani ; Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

Abstract

In the present work, we prepared a simple and novel electrochemical sensor based on zeolitic imidazolate framework-67 (ZIF-67) and ionic liquid 1-Butyl-3-methylimidazolium hexa­fluorophosphate (BMIM.PF6) modified carbon paste electrode (CPE), which was effectively used for the determination of N-acetylcysteine. The cyclic voltammetry studies demonstrated the lowest peak potential and the enhanced peak current response for N-acetyl­cysteine at the surface of ZIF-67/BMIM.PF6-modified CPE compared to the other CPEs due to the significant catalytic effect of ZIF-67 and BMIM.PF6, as well as the combination of them. Under the optimized conditions, the electrochemical response of ZIF-67/BMIM.PF6/CPE sensor provided a good linear relationship with N-acetylcysteine concentration from 0.04 to 435.0 µM. The limit of detection is estimated to be 0.01 μM for N-acetylcysteine. In further studies and measurements, the estimation of N-acetylcysteine in tablet samples confirms the usefulness of the ZIF-67/BMIM.PF6/CPE sensor.

Keywords

Zeolitic imidazolate framework-67; Ionic liquid; carbon paste electrode; metal-organic framework; nanomaterials

Hrčak ID:

314033

URI

https://hrcak.srce.hr/314033

Publication date:

29.11.2023.

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