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Acta clinica Croatica, Vol. 62. No. 3, 2023.

Original scientific paper

https://doi.org/10.20471/acc.2023.62.03.2

Biofilm and Histopathological Grading of Maxillary Sinus Mucosa in Patients with Antrochoanal Polyps

Gorazd Poje orcid id orcid.org/0000-0001-7159-7834 ; Department of Otolaryngology & Head and Neck Surgery, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia
Mario Bilić orcid id orcid.org/0000-0002-2525-9524 ; Department of Otolaryngology & Head and Neck Surgery, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia *
Krsto Dawidowsky ; Department of Otolaryngology & Head and Neck Surgery, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia
Lana Kovač Bilić orcid id orcid.org/0000-0003-2526-2261 ; Department of Otolaryngology & Head and Neck Surgery, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia

* Corresponding author.

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Abstract

The aim of this cross-sectional study was to determine the signs of biofilm in the
maxillary sinus of patients with antrochoanal polyps (ACP), and status of the mucosa on which the
biofilm occurred. Mucosal samples from maxillary sinus in 40 ACP patients who underwent endoscopic
sinus surgery were analyzed histopathologically and by scanning electron microscopy. Results
were compared with maxillary mucosa samples of 40 patients without endoscopic and radiological
signs of sinus disease. The existence of biofilm and its relation to the degree of histopathological
changes according to Terrier classification of chronic mucosal inflammation of maxillary sinus were
statistically analyzed. Biofilm was detected in 23 of 40 (57.5%) ACP patients; the incidence was significantly
lower in the control group (2/40, 5%). Biofilm was not found in type 1 mucosa according
to Terrier classification. In conclusion, biofilm showed a significant incidence in the maxillary sinus
mucosa of ACP patients (57.5%). Occasionally, biofilm can be found in patients with no signs of
sinus disease, but not on histologically normal mucosa. Results of this study support the theory that
biofilm formation does not represent the initial stage of the inflammatory process.

Keywords

Antrochoanal polyp; Biofilm; Maxillary sinus

Hrčak ID:

314857

URI

https://hrcak.srce.hr/314857

Publication date:

1.11.2023.

Article data in other languages: croatian

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