Review article
https://doi.org/10.26800/LV-146-supl1-15
Development of the immune system and exposure to infections
Alenka Gagro
orcid.org/0000-0001-6308-6460
Abstract
Infections are one of the first signs of many inborn errors of immunity. Infections are seen more often in children, which is usually explained by the physiological immaturity of the immune system. Rational assessment of which children should be tested further is a challenge for everyday practice. In this review, along with a reminder of the peculiarities of immune maturation in children, the specifics of history, status, basic and complex immunological analysis as well as genetic testing are described for the purpose of early recognition of children with infections and inborn errors of immunity. Special emphasis was also placed on the paradigm shift in the recognition of these disorders in children with infections by common pathogens and a severe clinical picture of the infection. Through good cooperation at all levels of health care for children, we will ensure, with timely recognition, proper treatment and prevention of complications as well as unfavorable disease outcomes in children with inborn errors of immunity.
Keywords
INFECTIONS; INBORN ERRORS OF IMMUNITY; EARLY RECOGNITION; IMMUNOLOGICAL ANALYSIS; GENETIC ANALYSIS; TREATMENT; PREVENTION
Hrčak ID:
315829
URI
Publication date:
11.4.2024.
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