Review article

Chronic Inflammation in Patients with Solid Organ Transplant

Jerko Barbić

Abstract

SUMMARY Organ transplantation is the optimal therapy for end-stage kidney disease. There are numerous factors related to the donor that affect the outcome of a kidney transplantation. The differences between living and deceased kidney donors are very well known. The transplanted organ is exposed to different forms of damage at different stages of organ transplantation. In the early phase, brain death of the donor and ischemia of the transplanted organ stimulate the release of damage-associated molecular patterns (DAMP) that activate inflammation in the transplanted organ. In addition to local inflammation, inflammation can also be systemic. Local inflammation in the transplanted organ promotes the activity of acquired immunity and causes chronic rejection. Chronic inflammation and activated acquired immunity lead to chronic local inflammation that disrupts the healing process causing fibrosis and ultimately loss of function of the transplanted organ. Systemic chronic inflammation can be associated with insulin resistance, obesity, diabetes, arterial hypertension, which all together represent a risk factor for general and cardiovascular morbidity and mortality in transplant patients.

Keywords

inflammation; transplantation; cytokines; damage-associated molecular patterns

Hrčak ID:

315850

URI

https://hrcak.srce.hr/315850

Publication date:

9.4.2024.

Article data in other languages: croatian

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