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Acta clinica Croatica, Vol. 62. No. 4, 2023.

Original scientific paper

https://doi.org/10.20471/acc.2023.62.04.3

The Role of Plasma Copeptin Level in Determining the Severity and Mortality of Subarachnoid Hemorrhage

Seda Ozkan orcid id orcid.org/0000-0003-1835-8820 ; Department of Emergency Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey *
Necmi Baykan orcid id orcid.org/0000-0002-6845-9550 ; Department of Emergency Medicine, Kayseri City Hospital, Kayseri, Turkey
Omer Salt orcid id orcid.org/0000-0002-5557-6627 ; Department of Emergency Medicine, Kayseri City Hospital, Kayseri, Turkey
Sule Yakar ; Department of Emergency Medicine, Kayseri City Hospital, Kayseri, Turkey
Ahmet Sen ; Department of Biochemistry, Van Training and Research Hospital, Van, Turkey
Polat Durukan ; Department of Emergency Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey

* Corresponding author.

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Abstract

The study aimed to investigate the role of plasma copeptin level in setting the diagnosis,
severity and mortality of patients with subarachnoid hemorrhage (SAH) admitted to the emergency
department. We included patients aged ≥18 years who were diagnosed with SAH. Blood samples
were collected from patients at the time of admission to the emergency department for assessment of
plasma copeptin levels. The Glasgow Coma Scale (GCS), World Federation of Neurological Surgeons
(WFNS), modified Fisher score, in-hospital mortality and one-year mortality rates were determined
in patients. There was a statistically significant difference in plasma copeptin levels between the patients
(mean: 0.78±0.41 ng/mL) and healthy controls (mean: 0.48±0.27 ng/mL) (p=0.001). There was
no significant correlation of plasma copeptin levels with the GCS, WFNS, and modified Fisher scores.
There was no significant difference in copeptin levels between the patients who died in the hospital
(mean: 0.73±0.42 ng/mL) and those who did not (mean: 0.80±0.41 ng/mL) (p=0.41). Although plasma
copeptin level may be used in the diagnosis of SAH, it does not have a role in determining the patient
condition severity and mortality.

Keywords

Copeptin; Emergency department; Mortality; Subarachnoid hemorrhage

Hrčak ID:

320266

URI

https://hrcak.srce.hr/320266

Publication date:

31.12.2023.

Article data in other languages: croatian

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