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Acta clinica Croatica, Vol. 62. No. 4, 2023.

Original scientific paper

https://doi.org/10.20471/acc.2023.62.04.16

Retrospective Observational Study of Vitamin D Status in Neurological Patients

Lucija Zadro Matovina orcid id orcid.org/0009-0007-2350-4702 ; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University of Zagreb, School of Dental Medicine, Zagreb, Croatia *
Helena Trputac ; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Antonia Nicinger ; Department of Neurology, Virovitica General Hospital, Virovitica, Croatia
Petra Magdalena Kes ; University of Zagreb, School of Dental Medicine, Zagreb, Croatia
Vanja Bašić Kes ; Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University of Zagreb, School of Dental Medicine, Zagreb, Croatia

* Corresponding author.

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Abstract

The main objective of this study was to investigate the prevalence of insufficient serum
25-hydroxyvitamin D level in a sample of neurological patients and to compare it to the estimate in
the general Croatian population. The secondary aim was to test for the possible significant differences in
vitamin D2 insufficiency between the groups of patients according to gender, season, region, vitamin D3
supplementation, and diagnosis of autoimmune disease. This retrospective study involved 371 neurological
patients in one-year period. The data collected included gender, age at the time of admission, region,
season at the time of admission, main neurological diagnosis at discharge, serum 25-hydroxyvitamin D
level at the time of hospitalization, and use of vitamin D3 substitutes prior to hospitalization. The proportion
of neurological patients with 25-hydroxyvitamin D insufficiency (<75 nmol/L) was estimated at
74.66% (95% confidence interval, p<0.0001), which is slightly lower than in the Croatian general population.
There were no significant differences in 25-hydroxyvitamin D insufficiency according to gender,
season and region. Significant differences in 25-hydroxyvitamin D insufficiency were found according to
vitamin D3 supplementation and diagnosis of autoimmune disease.

Keywords

Vitamin D deficiency; Multiple sclerosis; Autoimmune diseases

Hrčak ID:

320576

URI

https://hrcak.srce.hr/320576

Publication date:

31.12.2023.

Article data in other languages: croatian

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