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Archives of Industrial Hygiene and Toxicology, Vol. 59 No. 4, 2008.

Original scientific paper

https://doi.org/10.2478/10004-1254-59-2008-1907

Asbestosis and Catalase Genetic Polymorphism

Alenka Franko ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia
Vita Dolžan ; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Niko Arnerić ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia
Metoda Dodič-Fikfak ; Clinical Institute of Occupational, Traffic and Sports Medicine, University Medical Centre, Ljubljana, Slovenia

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Abstract

Catalase (CAT) is part of the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis. This study investigates whether CAT -262 C>T genetic polymorphism influences the risk of asbestosis in workers occupationally exposed to asbestos.
The nested case-control study included 262 cases with asbestosis and 265 controls with no asbestosrelated disease. Data on cumulative asbestos exposure and smoking were available. A real-time PCR assay was introduced for genotyping CAT -262 C>T promoter polymorphism.
A slightly elevated risk of asbestosis was observed in subjects with the CAT -262 TT genotype compared to others (OR=1.36, CI 0.70-2.62). This risk did not change substantially after adjustment by sex, age, and smoking, but the involvement of cumulative asbestos exposure changed the OR to 1.91 (CI 0.93-3.91).
These findings indicate that the CAT -262 TT genotype may be slightly associated with an increased risk of asbestosis. No synergistic effect was found between cumulative asbestos exposure and the CAT -262 TT genotype, but cumulative asbestos exposure acted as a confounder. These results are an important contribution to understanding the interactions between genetic and environmental factors that may modify the risk of asbestosis.

Keywords

asbestos exposure; causal relationship; nested case control study; real-time PCR

Hrčak ID:

29524

URI

https://hrcak.srce.hr/29524

Publication date:

8.12.2008.

Article data in other languages: slovenian

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