Acta clinica Croatica, Vol. 63. No. 1, 2024.
Original scientific paper
https://doi.org/10.20471/acc.2024.63.01.13
Serum activity of antioxidative enzymes and concentration of malondialdehyde as predictors of colorectal cancer stage in Croatian patients
Ana Mojsović Ćuić
; University of Applied Health Sciences, Zagreb, Croatia
*
Lana Feher Turković
; University of Applied Health Sciences, Zagreb, Croatia
Sandra Domjanić Drozdek
; University of Applied Health Sciences, Zagreb, Croatia;
Ivan Jurak
; University of Applied Health Sciences, Zagreb, Croatia
Domagoj Đikić
; Division of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Irena Landeka Jurčević
; Laboratory of Chemistry and Food Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Marija Skoko
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Nina Rotim
; student, School of Medicine, University of Zagreb, Zagreb, Croatia
Danko Velimir Vrdoljak
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Nikola Đaković
; Institute for Clinical Medical Research and Teaching, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
* Corresponding author.
Abstract
One of the factors involved in the colorectal cancer development is intracellular
oxidative stress and antioxidative imbalance. The study aimed to explore the link between oxidative
stress measured by the activity of antioxidative markers and lipid peroxidation product malondialdehyde
(MDA) as possible cancer predictors of colorectal cancer by using several statistical methods. The study
included 50 adult colorectal cancer patients of both genders. MDA level, the activity of antioxidative
markers superoxide dismutase and catalase, and glutathione concentration were determined in
patient sera. There was no age difference between male and female patients (p=0.579), and no gender
differences according to cancer site (p=0.995), stage (p=0.083), and size (p=0.245). Th ere were no
differences in the levels of studied enzymes. Correlation analysis of antioxidative markers and MDA
with cancer size and patient age revealed strongest individual correlation between the MDA and
cancer size variables (r=-0.56).
Keywords
Colorectal cancer; Oxidative stress; Antioxidative markers; Malondialdehyde
Hrčak ID:
322038
URI
Publication date:
1.4.2024.
Visits: 51 *