Original scientific paper
https://doi.org/10.3325/cmj.2023.64.256
A pattern of antibiotic drug resistance of Salmonella Typhi and Salmonella Paratyphi among children with enteric fever in a tertiary care hospital in Lahore, Pakistan
Usman Baig
; Department of Pediatrics, Sharif Medical City Hospital, Lahore, Pakistan
*
Syed Muslim Mehdi
; Department of Pediatrics, Sharif Medical City Hospital, Lahore, Pakistan
Nosheen Iftikhar
; Department of Pediatrics, Sharif Medical City Hospital, Lahore, Pakistan
* Corresponding author.
Abstract
Aim To establish the pattern of antibiotic resistance and assess the frequency of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Salmonella Typhi and
Salmonella Paratyphi among children with enteric fever.
Methods This cross-sectional study was carried out in the
Department of Pediatrics, Sharif Medical City Hospital, Lahore, from July 2020 to January 2021. The study involved
patients aged between 0 to 15 years who attended our
outpatient department or were admitted to the ward with
the suspicion of typhoid fever. A convenience sample of
patients with blood cultures positive for S. Typhi and S.
Paratyphi was enrolled.
Results Of the 105 participants, 70 (66.7%) were male.
The mean age was 8.48±4.18 years, and the most affected age group was 6-10 years (n=46, 43.8%). Among the
cultured organisms, 95 (90.5%) isolates were S. Typhi and
10 (9.5%) were S. Paratyphi A. Antibiotic resistance was
highest against ampicillin (n=91, 86.7%), and all of the isolates were sensitive to imipenem and meropenem. Twenty-three (21.9%) cultured organisms were MDR and 54
(56.8%) were XDR.
Conclusion An alarming antibiotic drug resistance pattern was observed among children with enteric fever in
Lahore. The lowest resistance was noted for azithromycin,
meropenem, and imipenem. Our findings warrant the immediate implementation of tailored antibiotic stewardship
and infection control strategies.
Keywords
Hrčak ID:
331840
URI
Publication date:
31.8.2023.
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