Professional paper
Progressive multifocal leukoencephalopathy (PML) in HIV-infected patients – a case report and review of patients treated at the University Hospital for Infectious Diseases in Zagreb
Tomislav Maretić
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Rok Čivljak
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Miroslav Lisić
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Davorka Lukas
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Klaudija Višković
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Josip Begovac
; Klinika za infektivne bolesti Dr.Fran Mihaljević, Zagreb
Abstract
HIV-infection with advanced immunodeficiency was diagnosed in a forty-year-old female patient with gradual and progressive development of neurological symptoms. Based on neurological symptoms (cognitive and motor deficits, speech, vision and muscular tonus disorders, coordination disturbances) as well as neuroradiological imaging, progressive multifocal leukoencephalopathy (PML) was diagnosed. Subsequently, the diagnosis of PML was confirmed with positive cerebrospinal fluid (CSF) polymerase chain reaction (PCR) for JC virus. The patient was treated with antiretroviral drugs together with other symptomatic and supportive therapy. Despite somewhat improved laboratory parameters of acquired immunodeficiency after five-month therapy, the disease continued to progress and resulted in fatal outcome. In the last 20 years, altogether 11 HIV-infected patients were diagnosed with PML in our hospital based on clinical/neurological manifestations and neuroradiologic imaging findings. The details are presented in Table 2. In described case, for the first time in Croatia, the etiological diagnosis was confirmed with JC virus detection in the CSF.
Keywords
progressive multifocal leukoencephalopathy (PML); JC virus; human immunodeficiency virus (HIV); HIV-disease
Hrčak ID:
30497
URI
Publication date:
3.6.2008.
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