Croatica Chemica Acta, Vol. 81 No. 4, 2008.
Original scientific paper
Study on the Lewis Acid-promoted Aza-Diels – Alder Reaction of Azetidin-2-one-tethered Imines with Siloxydienes in the Asymmetric Synthesis of 2-Aryl(alkyl)-2,3-dihydro-4-pyridones
Tanja Poljak
; Ruđer Bošković Institute, Zagreb, Croatia; GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia
Krešimir Molčanov
; Ruđer Bošković Institute, Zagreb, Croatia
Davor Margetić
; Ruđer Bošković Institute, Zagreb, Croatia
Ivan Habuš
; Ruđer Bošković Institute, Zagreb, Croatia
Abstract
trans-3-Amino-b-lactams were evaluated as the chiral building blocks in the aza-Diels – Alder
reaction of azetidin-2-one-tethered imines with siloxydienes under Lewis acid catalysis, as a
route for the asymmetric synthesis of 2-aryl(alkyl)-2,3-dihydro-4-pyridones.
Keywords
beta-lactam; imine; pyridone; aza-Diels – Alder reaction; Lewis acid
Hrčak ID:
31180
URI
Publication date:
31.12.2008.
Visits: 2.422 *