Acta Pharmaceutica, Vol. 59 No. 1, 2009.
Short communication, Note
https://doi.org/10.2478/v10007-009-0004-0
Sinteza i farmakološka evaluacija 3-cikloheksil-2-supstituiranih hidrazino-3H-kinazolin-4-ona kao analgetika i antiinflamatorika
VEERACHAMY ALAGARSAMY
; Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy-502294, India
DURAIRAJ SHANKAR
; Department of Pharmacy (CARISM), SASTRA University, Tirumalaisamudram, Thanjavur-613 402, India
VISWAS RAJA SOLOMON
; Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
RAJENDRA VASANT SHEOREY
; Department of Pharmacology, Institute of Pharmacy, Raipur Institute of Technology Raipur-492001, India
PERIYASAMY PARTHIBAN
; Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy-502294, India
Abstract
Reakcijom amino skupine 3-cikloheksil-2-hidrazino kinazolin-4(3H)-ona s različitim aldehidima i ketonima sintetizirani su novi 3-cikloheksil-2-supstituirani hidrazino-kinazolin-4(3H)-oni. Početni spoj 3-cikoheksil-2-hidrazino kinazolin-4(3H)-on pripravljen je iz cikloheksilamina. Sintetizirani spojevi testirani su na analgetsko i protuupalno djelovanje te ulcerogena svojstva. Spoj 3-cikloheksil-2-(1-metilbutiliden-hidrazino)-3H-kinazolin-4-on (4c) imao je najjače analgetsko i protuupalno djelovanje, nešto jače nego referentni spoj diklofenak natrij. Osim toga, testirani spojevi imaju samo blago ulcerogeno djelovanje u usporedbi s acetilsalicilnom kiselinom.
Keywords
kinazolin-4(3H)-on; analgetsko djelovanje; protuupalno djelovanje; ulcerogenost
Hrčak ID:
31555
URI
Publication date:
1.3.2009.
Visits: 1.917 *