Original scientific paper

Pharmacokinetics of cefotaxime in hepatic-dysfunctioned buffalo calves

Suresh Kumar Sharma ; Department of Pharmacology and Toxicology, College of Veterinary Science Punjab Agricultural University, Ludhiana, India
Anil Kumar Srivastava ; Department of Pharmacology and Toxicology, College of Veterinary Science Punjab Agricultural University, Ludhiana, India
Milind Devidas Deore ; Bombay Veterinary College, Parel, Mumbai, India

Abstract

The pharmacokinetics, urinary excretion and dosage regimen of cefotaxime after its single intravenous administration (10 mg.kg-1) was investigated in hepatic-dysfunctioned buffalo calves. Hepatic-dysfunction was induced by intramuscular administration of paracetamol (250 mg.kg-1 body weight on day 1, followed by two subsequent doses of 50 mg.kg-1 body weight on day 3 and 5). At 1 min, the concentration of cefotaxime in plasma was 69.6 ± 1.54 μg.ml-1 which rapidly declined to 11.5 ± 0.41 μg.ml-1 at 15 min. The drug was detected upto 5 h. The elimination half-life and volume of distribution were 0.94 ± 0.02 h and 1.48 ± 0.07 L.kg-1, respectively. The distribution half-life and AUC were 0.055 ± 0.003 h and 9.20 ± 0.47 μg.ml-1.h, respectively. The total body clearance (ClB) and tissue/plasma (T/C) ratio were 1.1 ± 0.06 L.kg-1.h-1 and 11.5 ± 0.89, respectively. Approximately 3% of the total administered dose of cefotaxime was recovered in urine within 24 h after administration. Cefotaxime was bound to plasma proteins of hepatic-dysfunctioned buffalo calves to the extent of 31-35.2%. A satisfactory intravenous dosage regimen for cefotaxime in hepatic-dysfunctioned buffalo calves would be 13 mg/kg body weight at 6 h intervals.

Keywords

buffalo calves; cefotaxime; dosage regimen; hepatic dysfunction; pharmacokinetics

Hrčak ID:

31910

URI

https://hrcak.srce.hr/31910

Publication date:

19.8.2005.

Article data in other languages: croatian

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