Meeting abstract
Expression of PCNA and Ki-67 Antigens in Oral Lichen Ruber
Dolores Biočina-Lukenda
Ahmed Pirkić
Ana Cekić-Arambašin
Abstract
Oral Lichen Ruber (OLR) is a precancerous lesion of mucous membrane, according to WHO criteria.Increasing frequency of malignant alteration was observed among atrophic, erosive and ulcerous lesions. The aim of this investigation was to define possible malignant potential of OLR lesions by determining the expression intensity of PCNA and Ki-67 antigens, as indicators of activity and proliferation of these lesions. The aim was to determine expression of these antigens in lesions of OLR and compare with some clinical forms of these lesions. The investigation included 30 patients with OLR (N = 30) with clinical and pathologically confirmed diagnosis and a control group of patients with lesion of oral leukoplakia (OL) (N = 15). Clinical tests based on standard clinical tests and methods and biopsy samples were observed by immunohistochemical methods by specific monoclonal antibody. Results showed more statistically significant expression of PCNA and Ki-67 in OLR lesions than in OL lesions and expression was stronger in erosive than in planes forms of OLR.
It can be concluded that such altered expression of PCNA and Ki-67 antigens in OLR lesions points to the altered nature of those lesions with the potential to undergo malignant transformation.
Keywords
Hrčak ID:
3058
URI
Publication date:
15.9.2003.
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