Meeting abstract
Bacterial Adherence and its Importance in Pathogenesis of Oral Lichen Ruber
Ana Cekić-Arambašin
Dolores Biočina-Lukenda
J. Vraneš
Abstract
Oral lichen ruber (OLR) is a chronic, mucocutaneous autoimmune disease. The etiology of this oral disease is still not clear. It is assumed that some uncharacteristic antigens adher to keratinocyte surfaces and in that way change antigenic structure of keratinocytes, which can influence autoimmunity reaction. The aim of this investigation was to detect how much that hypothesis can be included in classical pathogenesis of OLR. We took cytological smears (N = 30) of OLR lesions (clinical and pathohistologically confirmed) before and after antibiotic therapy and comparedthem with the control group (N =30) of healthy subjects. Detection of that observation was done by Gramm and light microscopy method. Results showed a significant lower number of streptococcus and other bacterial microorganisms, which adhered to keratinocytes surfaces, after antibiotic therapy and compared with the control group. The clinical status was also better. These results can be a key step in the pathogenesis of OLR, and the mechanism and role of bacterial adherence to oral keratinocytes can be considered.
Keywords
Hrčak ID:
3133
URI
Publication date:
15.9.2003.
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