Original scientific paper
Serum and Tissue Angiotensin Converting Enzyme in Patients with Psoriasis
Jasminko Huskić
Nedžad Mulabegović
Faruk Alendar
Ljerka Ostojić
Zdenko Ostojić
Dubravka Šimić
Ruža Miličević
Mladenka Naletilić
Abstract
Recent evidence suggests that the angiotensin converting enzyme (ACE) is present in skin. The real value of the determination
of ACE activity as a clinical-biochemistry test for the diagnosis of psoriasis has not been attained. Serum and
tissue ACE were measured in 60 patients with psoriasis, 20 patients with lichen planus, 20 patients with seborrhoic dermatitis
and in 20 healthy individuals. The serum and tissue ACE activity was determined before and after therapy, using
the spectrophotometric method and hippuryl-l-histidyl-l-leucine as a substrate. The results showed that serum ACE
activity before therapy was significantly increased in both groups – patients with psoriasis (p<0.001) and patients with
lichen planus (p<0,001) in comparison to healthy individuals. However, there were no significant differences in serum
ACE activity among patients with seborrhoic dermatitis and healthy individuals. After therapy, serum ACE activity significantly
decreased in both groups of patients with psoriasis and patients with lichen planus comparing it to the level
found in the control group. The values in both were similar. The tissue ACE activity in altered skin was significantly increased
only in the patients with psoriasis in comparison to uninvolved skin of these patients, as well as the skin of
healthy individuals. After therapy, there were no significant differences in tissue ACE activity between the treated skin
and the healthy skin. In conclusion, determination of tissue angiotensin converting enzyme activity can be used in the
differential diagnostic of indistinct clinical forms of psoriasis.
Keywords
angiotensin converting enzyme; psoriasis; serum; tissue
Hrčak ID:
34308
URI
Publication date:
1.12.2008.
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